# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 21:54:13
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "Periventricular leukomalacia" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Periventricular leukomalacia	Uterine polyp	1	1	PLEKHG1 (2)	0.03846	0.50000	3.115e-3	4.096e-3	
Panic disorder	Periventricular leukomalacia	1	1	PLEKHG1 (2)	0.02778	0.50000	4.411e-3	5.528e-3	
Global developmental delay	Periventricular leukomalacia	1	1	RPS6KC1 (2)	0.00269	0.50000	4.748e-2	4.925e-2	
Cardiovascular disease	Periventricular leukomalacia	1	1	PLEKHG1 (2)	0.00230	0.50000	5.533e-2	5.699e-2	
Myocardial infarction	Periventricular leukomalacia	1	1	PLEKHG1 (2)	0.00172	0.50000	7.392e-2	7.527e-2