# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 10:07:06
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset" (14 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	1	0	PTRH2 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Metachromatic leukodystrophy	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	1	1	YARS1 (2)	0.11111	1.00000	5.165e-4	9.125e-4	214
Hyperinsulinemic hypoglycemia	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	1	1	YARS1 (2)	0.08333	1.00000	7.102e-4	1.174e-3	
Cholestasis	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	1	1	YARS1 (2)	0.05556	1.00000	1.098e-3	1.651e-3	
Liver failure	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	1	1	YARS1 (2)	0.01818	1.00000	3.487e-3	4.343e-3	
Anemia	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	1	1	YARS1 (2)	0.01163	1.00000	5.488e-3	6.515e-3	
Cerebellar ataxia	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	1	1	PTRH2 (2)	0.00820	1.00000	7.813e-3	8.931e-3	
Cerebellar ataxia	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	1	1	PTRH2 (2)	0.00820	1.00000	7.813e-3	8.931e-3	
Charcot-marie-tooth disease	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	1	1	PTRH2 (2)	0.00741	1.00000	8.652e-3	9.793e-3	
Charcot-marie-tooth disease	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	1	1	PTRH2 (2)	0.00741	1.00000	8.652e-3	9.793e-3	
Hearing loss	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	1	1	PTRH2 (2)	0.00251	1.00000	2.563e-2	2.720e-2	
Hearing loss	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	1	1	PTRH2 (2)	0.00251	1.00000	2.563e-2	2.720e-2	
Global developmental delay	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	1	1	PTRH2 (2)	0.00229	1.00000	2.815e-2	2.962e-2	
Global developmental delay	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	1	1	PTRH2 (2)	0.00229	1.00000	2.815e-2	2.962e-2