# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 03:50:52
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Neurodevelopmental disorder with spastic paraplegia and brain abnormalities" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Mental retardation, autosomal recessive 58	Neurodevelopmental disorder with spastic paraplegia and brain abnormalities	1	0	ELP2 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Complex neurodevelopmental disorder with motor features	Neurodevelopmental disorder with spastic paraplegia and brain abnormalities	1	1	ELP2 (2)	0.12500	1.00000	4.520e-4	8.260e-4	
Neurodevelopmental disorder with spastic paraplegia and brain abnormalities	Oligodendroglioma	1	1	ELP2 (2)	0.00157	1.00000	4.093e-2	4.253e-2	
Intellectual developmental disorder	Neurodevelopmental disorder with spastic paraplegia and brain abnormalities	1	1	ELP2 (6)	0.00123	1.00000	5.262e-2	5.418e-2	
Major depressive disorder	Neurodevelopmental disorder with spastic paraplegia and brain abnormalities	1	1	ELP2 (2)	0.00051	1.00000	1.265e-1	1.273e-1