# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 19:03:09
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "NOG-related symphalangism spectrum disorder" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
NOG-related symphalangism spectrum disorder	Proximal symphalangism	1	1	NOG (2)	0.50000	1.00000	6.494e-5	2.329e-4	
Hemimelia of limb	NOG-related symphalangism spectrum disorder	1	1	NOG (2)	0.33333	1.00000	1.299e-4	3.929e-4	
Multiple synostoses syndrome	NOG-related symphalangism spectrum disorder	1	1	NOG (5)	0.20000	1.00000	2.598e-4	6.505e-4	
Brachydactyly	NOG-related symphalangism spectrum disorder	1	1	NOG (6)	0.04545	1.00000	1.364e-3	2.147e-3	
Complete unilateral cleft lip	NOG-related symphalangism spectrum disorder	1	1	NOG (2)	0.02703	1.00000	2.338e-3	3.242e-3