# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 03:13:53
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Mental retardation, autosomal recessive, 6" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Mental retardation, autosomal recessive, 6	Neurodevelopmental disorder with impaired language and ataxia and with or without seizures	1	0	GRIK2 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Lymphatic metastasis	Mental retardation, autosomal recessive, 6	1	1	GRIK2 (2)	0.03333	1.00000	1.872e-3	2.572e-3	
Carotid artery disease	Mental retardation, autosomal recessive, 6	1	1	GRIK2 (2)	0.01818	1.00000	3.487e-3	4.343e-3	
Bell's palsy	Mental retardation, autosomal recessive, 6	1	1	GRIK2 (2)	0.01754	1.00000	3.616e-3	4.491e-3	
Huntington disease	Mental retardation, autosomal recessive, 6	1	1	GRIK2 (2)	0.01613	1.00000	3.939e-3	4.834e-3