# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-22 05:11:05
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-22 03:00:19. Filters applied: disease name contains "Lethal occipital encephalocele-skeletal dysplasia syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies	Lethal occipital encephalocele-skeletal dysplasia syndrome	1	1	CYP26B1 (2)	0.50000	1.00000	6.457e-5	1.985e-4	
Lethal occipital encephalocele-skeletal dysplasia syndrome	Mouth disease	1	1	CYP26B1 (3)	0.05000	1.00000	1.227e-3	1.809e-3	
Craniosynostosis	Lethal occipital encephalocele-skeletal dysplasia syndrome	1	1	CYP26B1 (2)	0.01408	1.00000	4.520e-3	5.479e-3	
Colorectal adenoma	Lethal occipital encephalocele-skeletal dysplasia syndrome	1	1	CYP26B1 (2)	0.00498	1.00000	1.291e-2	1.425e-2	
Desbuquois syndrome	Lethal occipital encephalocele-skeletal dysplasia syndrome	1	1	CYP26B1 (2)	0.00177	1.00000	3.648e-2	3.803e-2