# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-22 02:19:52
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-22 03:00:19. Filters applied: disease name contains "Lacticacidemia" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Lacticacidemia	Pyruvate dehydrogenase E3 deficiency	1	0	PDHX (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Lacticacidemia	Leigh syndrome	1	1	PDHX (3)	0.00909	1.00000	7.038e-3	8.164e-3	
Lacticacidemia	Obsessive-compulsive disorder	1	1	PDHX (2)	0.00427	1.00000	1.504e-2	1.643e-2	
Lacticacidemia	Mitochondrial disease	1	1	PDHX (4)	0.00402	1.00000	1.601e-2	1.741e-2	
Lacticacidemia	Uterine fibroid	1	1	PDHX (2)	0.00327	1.00000	1.969e-2	2.115e-2