# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 23:43:54
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-12 03:00:13. Filters applied: disease name contains "Lacrimoauriculodentodigital syndrome" (9 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Lacrimoauriculodentodigital syndrome	Ladd syndrome	3	3	FGFR3 (5), FGF10 (6), FGFR2 (7)	0.75000	1.00000	1.644e-12	1.922e-11	
Complete unilateral cleft lip	Lacrimoauriculodentodigital syndrome	3	3	FGFR3 (5), FGF10 (5), FGFR2 (4)	0.08108	1.00000	1.174e-8	9.363e-8	
Cleft lip	Lacrimoauriculodentodigital syndrome	3	3	FGFR3 (6), FGF10 (6), FGFR2 (4)	0.07895	1.00000	1.277e-8	1.015e-7	
Craniofacial dysostosis	Lacrimoauriculodentodigital syndrome	2	2	FGFR3 (5), FGFR2 (4)	0.40000	0.66667	7.592e-8	5.413e-7	
Lacrimoauriculodentodigital syndrome	Saethre-chotzen syndrome	2	2	FGFR3 (5), FGFR2 (6)	0.40000	0.66667	7.592e-8	5.413e-7	
Aplasia of lacrimal and salivary glands	Lacrimoauriculodentodigital syndrome	1	1	FGF10 (6)	0.25000	1.00000	1.948e-4	5.354e-4	
Achondroplasia	Lacrimoauriculodentodigital syndrome	1	1	FGFR3 (6)	0.25000	1.00000	1.948e-4	5.354e-4	
Camptodactyly, tall stature, and hearing loss syndrome	Lacrimoauriculodentodigital syndrome	1	1	FGFR3 (6)	0.25000	1.00000	1.948e-4	5.354e-4	
Lacrimoauriculodentodigital syndrome	Salivary gland agenesis	1	1	FGF10 (5)	0.25000	1.00000	1.948e-4	5.354e-4