# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 06:53:15
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Intellectual developmental disorder with epilepsy" (10 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
ATP6AP2-related disorder	Intellectual developmental disorder with epilepsy	1	1	ATP6AP2 (2)	0.50000	1.00000	6.457e-5	1.985e-4	
Intellectual developmental disorder seizures behavioral	Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	1	1	ALG14 (4)	0.50000	1.00000	6.457e-5	1.985e-4	
Intellectual developmental disorder with epilepsy	Parkinsonism with spasticity, x-linked	1	1	ATP6AP2 (4)	0.50000	1.00000	6.457e-5	1.985e-4	
Intellectual developmental disorder with epilepsy	X-linked parkinsonism-spasticity syndrome	1	1	ATP6AP2 (4)	0.50000	1.00000	6.457e-5	1.985e-4	
Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	Myasthenic syndrome, congenital, 15, without tubular aggregates	1	0	ALG14 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	Myopathy, epilepsy, and progressive cerebral atrophy	1	0	ALG14 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Congenital myasthenic syndrome	Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	1	1	ALG14 (6)	0.03030	1.00000	2.066e-3	2.785e-3	
Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	Myasthenic syndrome	1	1	ALG14 (4)	0.02439	1.00000	2.583e-3	3.337e-3	
Intellectual developmental disorder with epilepsy	X-linked intellectual disability	1	1	ATP6AP2 (2)	0.01333	1.00000	4.778e-3	5.751e-3	
Intellectual developmental disorder with epilepsy	Intellectual developmental disorder, x-linked	1	1	ATP6AP2 (4)	0.01099	1.00000	5.811e-3	6.843e-3