# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 04:26:25
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Immunodeficiency 19" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Immunodeficiency 19	Severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive	1	1	CD3D (2)	0.25000	1.00000	1.937e-4	4.414e-4	
Immunodeficiency 19	T-B+ severe combined immunodeficiency	1	1	CD3D (2)	0.05556	1.00000	1.098e-3	1.651e-3	
Immunodeficiency 19	Severe combined immunodeficiency	1	1	CD3D (4)	0.01818	1.00000	3.487e-3	4.343e-3	
Allergic contact dermatitis	Immunodeficiency 19	1	1	CD3D (4)	0.01351	1.00000	4.713e-3	5.685e-3	
Biliary cirrhosis	Immunodeficiency 19	1	1	CD3D (3)	0.00775	1.00000	8.264e-3	9.403e-3