# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 18:06:54
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "Hypertension and brachydactyly syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Brachydactyly with hypertension	Hypertension and brachydactyly syndrome	1	1	PDE3A (4)	0.50000	1.00000	6.494e-5	2.329e-4	
Eye neoplasms	Hypertension and brachydactyly syndrome	1	1	PDE3A (2)	0.07692	1.00000	7.793e-4	1.405e-3	
Brachydactyly	Hypertension and brachydactyly syndrome	1	1	PDE3A (3)	0.04545	1.00000	1.364e-3	2.147e-3	
Hypertension and brachydactyly syndrome	Thrombosis	1	1	PDE3A (2)	0.02174	1.00000	2.922e-3	3.875e-3	
Hypertension and brachydactyly syndrome	Hypogonadism	1	1	PDE3A (2)	0.01299	1.00000	4.936e-3	6.051e-3