# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 06:37:02
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Gingival overgrowth" (11 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	Gingival overgrowth	1	0	KCNK4 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	Neurodevelopmental delay	1	0	KCNK4 (1)	0.14286	1.00000	3.874e-4	7.329e-4	
Gingival overgrowth	Neurodevelopmental delay	1	0	KCNK4 (1)	0.14286	1.00000	3.874e-4	7.329e-4	
Facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	Hypertrichosis	1	0	KCNK4 (1)	0.07692	1.00000	7.748e-4	1.247e-3	
Gingival overgrowth	Hypertrichosis	1	0	KCNK4 (1)	0.07692	1.00000	7.748e-4	1.247e-3	
Facial dysmorphism syndrome	Facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	1	1	KCNK4 (7)	0.05263	1.00000	1.162e-3	1.729e-3	
Facial dysmorphism syndrome	Gingival overgrowth	1	1	KCNK4 (7)	0.05263	1.00000	1.162e-3	1.729e-3	
Neurodevelopmental disorder with seizures and gingival overgrowth	Psychiatric disorders	1	1	TBC1D2B (2)	0.00452	1.00000	1.420e-2	1.561e-2	64
Facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	Seizures	1	0	KCNK4 (1)	0.00433	1.00000	1.485e-2	1.628e-2	
Gingival overgrowth	Seizures	1	0	KCNK4 (1)	0.00433	1.00000	1.485e-2	1.628e-2	
Neurodevelopmental disorder	Neurodevelopmental disorder with seizures and gingival overgrowth	1	1	TBC1D2B (4)	0.00099	1.00000	6.495e-2	6.624e-2