# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 18:06:30
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "Genetic syndromic pierre robin syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Genetic syndromic pierre robin syndrome	Mandibulofacial dysostosis	1	1	EFTUD2 (7)	0.12500	1.00000	4.546e-4	9.721e-4	
Esophageal atresia	Genetic syndromic pierre robin syndrome	1	0	EFTUD2 (1)	0.03030	1.00000	2.078e-3	2.968e-3	
Genetic syndromic pierre robin syndrome	Microcephaly	1	0	EFTUD2 (1)	0.00935	1.00000	6.884e-3	8.160e-3	
Genetic syndromic pierre robin syndrome	Global developmental delay	1	0	EFTUD2 (1)	0.00270	1.00000	2.403e-2	2.575e-2	
Endometriosis	Genetic syndromic pierre robin syndrome	1	1	EFTUD2 (2)	0.00265	1.00000	2.442e-2	2.615e-2