# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 03:55:45
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Epileptic encephalopathy, infantile or early childhood, 2" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Epileptic encephalopathy, infantile or early childhood, 2	Synovial disorder	1	1	GABRB2 (2)	0.14286	1.00000	3.874e-4	7.329e-4	
Complex neurodevelopmental disorder	Epileptic encephalopathy, infantile or early childhood, 2	1	1	GABRB2 (2)	0.00741	1.00000	8.652e-3	9.793e-3	
Epileptic encephalopathy, infantile or early childhood, 2	Post-traumatic stress disorder	1	1	GABRB2 (2)	0.00490	1.00000	1.311e-2	1.444e-2	
Developmental and epileptic encephalopathy	Epileptic encephalopathy, infantile or early childhood, 2	1	1	GABRB2 (6)	0.00431	1.00000	1.491e-2	1.630e-2	
Epilepsy	Epileptic encephalopathy, infantile or early childhood, 2	1	1	GABRB2 (3)	0.00365	1.00000	1.763e-2	1.903e-2