# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-22 03:06:48
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-22 03:00:19. Filters applied: disease name contains "Early-onset neurodegenerative encephalopathy" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Early-onset neurodegenerative encephalopathy	Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum	1	0	TBCD (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Early-onset neurodegenerative encephalopathy	Seborrhea-like dermatitis with psoriasiform elements	1	1	TBCD (2)	0.33333	1.00000	1.291e-4	3.269e-4	
Early-onset neurodegenerative encephalopathy	Thiel-behnke corneal dystrophy	1	1	TBCD (2)	0.33333	1.00000	1.291e-4	3.269e-4	
Early-onset neurodegenerative encephalopathy	Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome	1	1	TBCD (6)	0.25000	1.00000	1.937e-4	4.415e-4	
Cortical development malformation	Early-onset neurodegenerative encephalopathy	1	1	TBCD (2)	0.03704	1.00000	1.679e-3	2.344e-3