# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 05:44:59
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Dominant retinopathy" (6 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Dominant retinopathy	Recessive retinopathy	6	0	IMPG1 (1), GUCY2D (1), PROM1 (1), RP1 (1), RPE65 (1), RDH12 (1)	0.66667	0.85714	2.558e-21	3.906e-20	
Dominant retinopathy	Stargardt disease	4	4	PROM1 (7), RPE65 (2), SNRNP200 (2), RDH12 (2)	0.12500	0.57143	2.979e-10	2.687e-9	
Congenital blindness	Dominant retinopathy	2	2	GUCY2D (2), RPE65 (2)	0.22222	0.66667	5.252e-7	3.320e-6	
Dominant retinopathy	Retinal dystrophy	2	2	RPE65 (2), SNRNP200 (2)	0.08696	0.28571	2.374e-5	1.237e-4	
Benign concentric annular macular dystrophy	Dominant retinopathy	1	1	IMPG1 (4)	0.12500	1.00000	4.520e-4	8.260e-4	
Dominant retinopathy	Retinitis pigmentosa with choroidal involvement	1	1	RPE65 (6)	0.12500	1.00000	4.520e-4	8.260e-4