# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 08:38:08
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "Cold-induced sweating syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Cold-induced sweating syndrome	Crisponi syndrome	3	3	KLHL7 (4), CLCF1 (6), CRLF1 (7)	0.75000	1.00000	1.644e-12	1.922e-11	331
Bohring-opitz-like syndrome	Cold-induced sweating syndrome	1	1	KLHL7 (3)	0.25000	1.00000	1.948e-4	5.354e-4	331
Cold-induced sweating syndrome	Perching syndrome	1	1	KLHL7 (5)	0.25000	1.00000	1.948e-4	5.354e-4	331
Bohring syndrome	Cold-induced sweating syndrome	1	1	KLHL7 (3)	0.20000	0.50000	3.896e-4	8.665e-4	331
Cold-induced sweating syndrome	Esophageal ulcer	1	1	CRLF1 (5)	0.05882	0.33333	2.725e-3	3.665e-3