# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 22:36:35
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-12 03:00:13. Filters applied: disease name contains "Cerebrofacioarticular syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Cerebrofacioarticular syndrome	Van maldergem syndrome	2	2	FAT4 (6), DCHS1 (7)	0.66667	1.00000	8.436e-9	6.818e-8	
Cerebrofacioarticular syndrome	Periventricular nodular heterotopia	2	2	FAT4 (3), DCHS1 (3)	0.15385	1.00000	5.568e-7	3.406e-6	
Cerebrofacioarticular syndrome	FAT4-related neurodevelopmental disorder	1	1	FAT4 (2)	0.33333	1.00000	1.299e-4	3.931e-4	
Cerebrofacioarticular syndrome	Hennekam syndrome	1	1	FAT4 (5)	0.20000	0.50000	3.896e-4	8.665e-4	
Cerebrofacioarticular syndrome	Lymphedema	1	1	DCHS1 (2)	0.05556	0.50000	2.077e-3	2.969e-3