# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 12:32:20
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "CBL-related disorder" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
CBL-related disorder	Early onset vitamin b6 dependent epilepsy	1	1	CBL (2)	0.25000	1.00000	1.948e-4	5.354e-4	
CBL-related disorder	Myelomonocytic leukemia	1	1	CBL (5)	0.09091	1.00000	6.494e-4	1.241e-3	
CBL-related disorder	Cryptorchidism	1	1	CBL (3)	0.04762	1.00000	1.299e-3	2.063e-3	
CBL-related disorder	Vasculitis	1	1	CBL (3)	0.03333	1.00000	1.883e-3	2.762e-3	
CBL-related disorder	Growth disorder	1	1	CBL (2)	0.02778	1.00000	2.273e-3	3.191e-3