# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-13 08:55:56
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-13 03:00:13. Filters applied: disease name contains "Autoimmune interstitial lung disease-arthritis syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Autoimmune interstitial lung disease-arthritis syndrome	Autoinflammation and autoimmunity, systemic, with immune dysregulation 1	1	1	COPA (5)	0.33333	1.00000	1.299e-4	3.931e-4	
Autoimmune interstitial lung disease-arthritis syndrome	Cold autoinflammatory syndrome	1	1	NLRP12 (4)	0.12500	0.50000	7.792e-4	1.405e-3	
Arthritis	Autoimmune interstitial lung disease-arthritis syndrome	1	1	COPA (5)	0.03571	0.50000	3.374e-3	4.374e-3	
Autoimmune interstitial lung disease-arthritis syndrome	Autoinflammatory syndrome	1	0	NLRP12 (1)	0.02564	0.50000	4.800e-3	5.921e-3	
Autoimmune interstitial lung disease-arthritis syndrome	Bell's palsy	1	1	NLRP12 (2)	0.01724	0.50000	7.261e-3	8.574e-3