# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-12 01:04:32
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-12 03:00:13. Filters applied: disease name contains "Adams-oliver syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Adams-oliver syndrome	NOTCH1-related AOS spectrum disorder	1	1	NOTCH1 (3)	0.14286	1.00000	3.897e-4	8.665e-4	
Adams-oliver syndrome	Aplasia cutis congenita	1	1	DLL4 (4)	0.09091	0.20000	1.947e-3	2.828e-3	
Adams-oliver syndrome	Congenital abnormalities	1	1	NOTCH1 (4)	0.05263	0.16667	5.056e-3	6.196e-3	
Adams-oliver syndrome	Congenital hydrocephalus	1	1	DOCK6 (3)	0.05000	0.16667	5.444e-3	6.629e-3	
Adams-oliver syndrome	Bicuspid aortic valve	1	1	NOTCH1 (4)	0.05000	0.16667	5.444e-3	6.629e-3