# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 09:23:07
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "ATP6AP2-related disorder" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
ATP6AP2-related disorder	Parkinsonism with spasticity, x-linked	1	1	ATP6AP2 (4)	0.50000	1.00000	6.494e-5	2.331e-4	
ATP6AP2-related disorder	X-linked parkinsonism-spasticity syndrome	1	1	ATP6AP2 (4)	0.50000	1.00000	6.494e-5	2.331e-4	
ATP6AP2-related disorder	X-linked intellectual disability	1	1	ATP6AP2 (2)	0.01333	1.00000	4.806e-3	5.921e-3	
ATP6AP2-related disorder	Intellectual developmental disorder, x-linked	1	1	ATP6AP2 (4)	0.01111	1.00000	5.780e-3	6.997e-3	
ATP6AP2-related disorder	Congenital disorder of glycosylation	1	1	ATP6AP2 (5)	0.01000	1.00000	6.429e-3	7.682e-3