# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 08:53:14
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "15q11q13 microduplication syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
15q11q13 microduplication syndrome	Duplication 15q11-q13 syndrome	1	1	UBE3A (2)	0.33333	1.00000	1.299e-4	3.931e-4	
15q11q13 microduplication syndrome	Angelman syndrome	1	1	UBE3A (7)	0.09091	1.00000	6.494e-4	1.241e-3	
15q11q13 microduplication syndrome	Developmental delay	1	1	UBE3A (2)	0.02564	1.00000	2.468e-3	3.371e-3	
15q11q13 microduplication syndrome	Developmental disability	1	1	UBE3A (2)	0.00694	1.00000	9.287e-3	1.059e-2	
15q11q13 microduplication syndrome	Craniofacial abnormalities	1	1	UBE3A (3)	0.00637	1.00000	1.013e-2	1.147e-2