# GeDiPNet Cluster 99 -- Enriched Pathways -- generated 2026-10-08 23:42:52
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Reactome	2	LRP5, SOST	8	10	300.25	1.743e-5	5.204e-4
Vitamin D (calciferol) metabolism	Reactome	2	LRP2, VDR	11	10	218.36	3.418e-5	9.099e-4
Parathyroid hormone synthesis, secretion and action	KEGG	3	LRP5, SOST, VDR	115	10	31.33	9.773e-5	2.145e-3
Regulation of FZD by ubiquitination	Reactome	2	LRP5, LGR4	21	10	114.38	1.299e-4	2.694e-3
Wnt signaling pathway	KEGG	3	LRP5, LGR4, SOST	174	10	20.71	3.328e-4	5.716e-3
Influenza Virus Induced Apoptosis	Reactome	1	TGFB1	2	10	600.50	1.665e-3	1.991e-2
TGFBR2 MSI Frameshift Mutants in Cancer	Reactome	1	TGFB1	2	10	600.50	1.665e-3	1.991e-2
TGFBR2 Kinase Domain Mutants in Cancer	Reactome	1	TGFB1	3	10	400.33	2.496e-3	2.680e-2
TGFBR1 LBD Mutants in Cancer	Reactome	1	TGFB1	4	10	300.25	3.327e-3	3.292e-2
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	Reactome	1	LRP5	6	10	200.17	4.986e-3	4.363e-2
SMAD2/3 Phosphorylation Motif Mutants in Cancer	Reactome	1	TGFB1	6	10	200.17	4.986e-3	4.363e-2
TGFBR1 KD Mutants in Cancer	Reactome	1	TGFB1	6	10	200.17	4.986e-3	4.363e-2
RUNX3 regulates CDKN1A transcription	Reactome	1	TGFB1	7	10	171.57	5.815e-3	4.839e-2
Gastric cancer	KEGG	2	LRP5, TGFB1	150	10	16.01	6.529e-3	5.247e-2
RNF mutants show enhanced WNT signaling and proliferation	Reactome	1	LRP5	8	10	150.13	6.644e-3	5.300e-2