# GeDiPNet Cluster 97 -- Enriched Pathways -- generated 2026-10-08 21:30:42
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Pathways of neurodegeneration - multiple diseases	KEGG	11	SNCA, TNF, LRRK2, MAPT, ATXN2, ATXN3, ND1, PARK7, PINK1, PRKN, SNCAIP	480	57	4.83	1.291e-5	4.221e-4
Parkinson disease	KEGG	8	SNCA, LRRK2, MAPT, ND1, PARK7, PINK1, PRKN, SNCAIP	268	57	6.29	3.549e-5	9.763e-4
Glycosphingolipid metabolism	Reactome	4	PSAP, SMPD1, ARSA, ARSB	46	57	18.32	6.414e-5	1.580e-3
Lysosome	KEGG	5	PSAP, SMPD1, SCARB2, ARSA, ARSB	133	57	7.92	4.076e-4	6.942e-3
Josephin domain DUBs	Reactome	2	ATXN3, PRKN	12	57	35.12	1.417e-3	1.812e-2
The activation of arylsulfatases	Reactome	2	ARSA, ARSB	13	57	32.42	1.669e-3	2.043e-2
Sphingolipid metabolism	KEGG	3	PSAP, SMPD1, ARSA	54	57	11.71	2.118e-3	2.428e-2
MPS VI - Maroteaux-Lamy syndrome	Reactome	1	ARSB	1	57	210.70	4.746e-3	4.296e-2
Pink/Parkin Mediated Mitophagy	Reactome	2	PINK1, PRKN	22	57	19.15	4.810e-3	4.336e-2
Mismatch repair	KEGG	2	MSH6, RFC1	23	57	18.32	5.252e-3	4.603e-2
Cytosolic tRNA aminoacylation	Reactome	2	YARS1, HARS1	24	57	17.56	5.712e-3	4.885e-2
Defective Mismatch Repair Associated With MSH6	Reactome	1	MSH6	2	57	105.35	9.470e-3	6.764e-2
NTF3 activates NTRK3 signaling	Reactome	1	NTRK3	2	57	105.35	9.470e-3	6.764e-2
Asthma	KEGG	2	TNF, HLA-DRA	32	57	13.17	1.002e-2	7.001e-2
Defective Mismatch Repair Associated With MSH2	Reactome	1	MSH6	3	57	70.23	1.417e-2	8.639e-2