# GeDiPNet Cluster 95 -- Enriched Pathways -- generated 2026-10-08 16:56:19
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Ferroptosis	KEGG	8	TF, SLC11A2, STEAP3, TFRC, CP, FTH1, FTL, HMOX1	42	34	67.28	1.874e-13	4.359e-11
Iron uptake and transport	Reactome	6	TF, SLC11A2, CP, FTH1, FTL, HMOX1	28	34	75.69	1.165e-10	1.574e-8
Mineral absorption	KEGG	5	TF, SLC11A2, FTH1, FTL, HMOX1	61	34	28.95	7.107e-7	3.616e-5
Transferrin endocytosis and recycling	Reactome	4	TF, STEAP3, TFRC, HFE	31	34	45.58	1.596e-6	7.271e-5
Porphyrin metabolism	KEGG	4	CP, FTH1, FTL, HMOX1	46	34	30.72	8.030e-6	2.865e-4
TGF-beta signaling pathway	KEGG	5	TF, TNF, TFRC, BMP2, HFE	108	34	16.35	1.211e-5	4.004e-4
Metal ion SLC transporters	Reactome	2	SLC11A2, CP	9	34	78.50	2.766e-4	5.100e-3
Golgi Associated Vesicle Biogenesis	Reactome	3	TFRC, FTH1, FTL	56	34	18.92	5.187e-4	8.361e-3
Necroptosis	KEGG	4	TNF, JAK2, FTH1, FTL	159	34	8.89	1.007e-3	1.397e-2
Hematopoietic cell lineage	KEGG	3	TNF, TFRC, ITGA2	100	34	10.60	2.779e-3	2.968e-2
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	Reactome	1	SLC11A2	1	34	353.24	2.831e-3	3.003e-2
Pre-NOTCH Transcription and Translation	Reactome	2	AGO2, E2F3	31	34	22.79	3.436e-3	3.438e-2
Interleukin-4 and Interleukin-13 signaling	Reactome	3	TNF, JAK2, HMOX1	108	34	9.81	3.455e-3	3.450e-2
HIF-1 signaling pathway	KEGG	3	TF, TFRC, HMOX1	110	34	9.63	3.639e-3	3.585e-2
Detoxification of Reactive Oxygen Species	Reactome	2	SOD1, GPX1	34	34	20.78	4.123e-3	3.916e-2