# GeDiPNet Cluster 88 -- Enriched Pathways -- generated 2026-10-07 22:08:35
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Gap junction assembly	Reactome	3	GJA1, GJB3, GJB4	18	25	80.07	6.369e-6	2.353e-4
Nef mediated downregulation of MHC class I complex cell surface expression	Reactome	2	AP1B1, AP1S1	10	25	96.08	1.853e-4	3.725e-3
Miscellaneous transport and binding events	Reactome	2	ANKH, NIPAL4	25	25	38.43	1.212e-3	1.608e-2
MHC class II antigen presentation	Reactome	3	AP2S1, AP1B1, AP1S1	123	25	11.72	2.045e-3	2.364e-2
Retinoid metabolism disease events	Reactome	1	RBP4	1	25	480.40	2.082e-3	2.394e-2
Lysosome Vesicle Biogenesis	Reactome	2	AP1B1, AP1S1	35	25	27.45	2.373e-3	2.643e-2
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome	1	POMC	2	25	240.20	4.159e-3	3.931e-2
Peptide hormone biosynthesis	Reactome	1	POMC	2	25	240.20	4.159e-3	3.931e-2
EPH-ephrin mediated repulsion of cells	Reactome	2	EPHA2, AP2S1	50	25	19.22	4.794e-3	4.328e-2
Golgi Associated Vesicle Biogenesis	Reactome	2	AP1B1, AP1S1	56	25	17.16	5.980e-3	5.030e-2
Regulation of gap junction activity	Reactome	1	GJA1	3	25	160.13	6.232e-3	5.168e-2
Opioid Signalling	Reactome	1	POMC	3	25	160.13	6.232e-3	5.168e-2
Cortisol synthesis and secretion	KEGG	2	GNA11, POMC	65	25	14.78	7.986e-3	6.075e-2
Human immunodeficiency virus 1 infection	KEGG	3	GNA11, AP1B1, AP1S1	213	25	6.77	9.488e-3	6.774e-2
Insulin secretion	KEGG	2	GNA11, TRPM4	86	25	11.17	1.366e-2	8.453e-2