# GeDiPNet Cluster 87 -- Enriched Pathways -- generated 2026-10-09 02:46:11
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Tyrosine metabolism	KEGG	4	MAOA, ADH1B, ADH1C, DBH	36	84	15.89	1.106e-4	2.369e-3
Ethanol oxidation	Reactome	2	ADH1B, ADH1C	12	84	23.83	3.048e-3	3.093e-2
Fatty acid degradation	KEGG	3	ADH1B, ADH1C, GCDH	43	84	9.98	3.329e-3	3.293e-2
Defective MAOA causes Brunner syndrome (BRUNS)	Reactome	1	MAOA	1	84	142.98	6.994e-3	5.469e-2
Receptor-type tyrosine-protein phosphatases	Reactome	2	PTPRD, PTPRF	20	84	14.30	8.463e-3	6.226e-2
Synaptic adhesion-like molecules	Reactome	2	PTPRD, PTPRF	21	84	13.62	9.312e-3	6.621e-2
Enzymatic degradation of Dopamine by monoamine oxidase	Reactome	1	MAOA	2	84	71.49	1.394e-2	8.475e-2
Metabolism of serotonin	Reactome	1	MAOA	2	84	71.49	1.394e-2	8.475e-2
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	Reactome	1	MAOA	2	84	71.49	1.394e-2	8.475e-2
NOTCH4 Activation and Transmission of Signal to the Nucleus	Reactome	1	YWHAZ	2	84	71.49	1.394e-2	8.475e-2
Drug metabolism - cytochrome P450	KEGG	3	MAOA, ADH1B, ADH1C	73	84	5.88	1.445e-2	8.678e-2
Mitotic Telophase/Cytokinesis	Reactome	1	KIF23	3	84	47.66	2.084e-2	1.075e-1
Enzymatic degradation of dopamine by COMT	Reactome	1	MAOA	3	84	47.66	2.084e-2	1.075e-1
IRE1alpha activates chaperones	Reactome	1	HSPA5	3	84	47.66	2.084e-2	1.075e-1
RUNX2 regulates osteoblast differentiation	Reactome	1	AR	3	84	47.66	2.084e-2	1.075e-1