# GeDiPNet Cluster 85 -- Enriched Pathways -- generated 2026-10-09 19:05:56
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Interleukin-4 and Interleukin-13 signaling	Reactome	7	MMP1, MMP3, HMOX1, ITGB2, TNF, TP53, IL1A	108	34	22.89	1.721e-8	1.328e-6
Coronavirus disease - COVID-19	KEGG	7	F2, MMP1, MMP3, ACE, MBL2, TNF, RPL36A-HNRNPH2	238	34	10.39	3.745e-6	1.450e-4
Rheumatoid arthritis	KEGG	5	MMP1, MMP3, ITGB2, TNF, IL1A	95	34	18.59	6.463e-6	2.250e-4
Complement and coagulation cascades	KEGG	4	F2, SERPINE1, ITGB2, MBL2	88	34	16.06	1.055e-4	2.288e-3
AGE-RAGE signaling pathway in diabetic complications	KEGG	4	SERPINE1, TNF, AGT, IL1A	101	34	13.99	1.800e-4	3.495e-3
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	4	APOE, F2, MMP1, SPP1	125	34	11.30	4.073e-4	6.729e-3
Fluid shear stress and atherosclerosis	KEGG	4	HMOX1, TNF, TP53, IL1A	141	34	10.02	6.422e-4	9.577e-3
Mineral absorption	KEGG	3	MT2A, HMOX1, VDR	61	34	17.37	6.669e-4	9.843e-3
Degradation of the extracellular matrix	Reactome	3	MMP1, MMP3, SPP1	70	34	15.14	9.969e-4	1.340e-2
Metabolism of Angiotensinogen to Angiotensins	Reactome	2	ACE, AGT	17	34	41.56	1.030e-3	1.372e-2
PPAR signaling pathway	KEGG	3	FABP2, MMP1, ADIPOQ	76	34	13.94	1.266e-3	1.611e-2
Pertussis	KEGG	3	ITGB2, TNF, IL1A	78	34	13.59	1.364e-3	1.705e-2
Leishmaniasis	KEGG	3	ITGB2, TNF, IL1A	78	34	13.59	1.364e-3	1.705e-2
Tuberculosis	KEGG	4	ITGB2, TNF, IL1A, VDR	181	34	7.81	1.625e-3	1.956e-2
Renin-angiotensin system	KEGG	2	ACE, AGT	23	34	30.72	1.896e-3	2.194e-2