# GeDiPNet Cluster 83 -- Enriched Pathways -- generated 2026-10-08 04:04:09
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Telomere Extension By Telomerase	Reactome	10	ACD, TERT, DKC1, GAR1, NHP2, NOP10, POT1, RTEL1, TINF2, WRAP53	16	62	121.07	4.905e-20	3.402e-17
rRNA modification in the nucleus and cytosol	Reactome	4	DKC1, GAR1, NHP2, NOP10	12	62	64.57	3.090e-7	1.759e-5
Allograft rejection	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	39	62	24.83	1.565e-6	7.144e-5
Leishmaniasis	KEGG	6	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF, JAK2	78	62	14.90	2.843e-6	1.205e-4
Type I diabetes mellitus	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	44	62	22.01	2.894e-6	1.221e-4
Graft-versus-host disease	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	45	62	21.52	3.243e-6	1.347e-4
Telomere C-strand synthesis initiation	Reactome	3	CTC1, POLA1, POLA2	7	62	83.02	4.519e-6	1.783e-4
Malaria	KEGG	5	CSF3, IFNG, TGFB1, TNF, ACKR1	50	62	19.37	5.514e-6	2.097e-4
Rheumatoid arthritis	KEGG	6	CSF2, IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF	95	62	12.23	8.987e-6	3.140e-4
Hematopoietic cell lineage	KEGG	6	CSF2, CSF3, HLA-DQA1, HLA-DQB1, THPO, TNF	100	62	11.62	1.208e-5	3.996e-4
Inflammatory bowel disease	KEGG	5	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF	66	62	14.67	2.183e-5	6.551e-4
DNA Damage/Telomere Stress Induced Senescence	Reactome	5	ACD, NBN, POT1, TINF2, TP53	66	62	14.67	2.183e-5	6.551e-4
Toxoplasmosis	KEGG	6	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF, JAK2	112	62	10.38	2.311e-5	6.877e-4
Removal of the Flap Intermediate	Reactome	3	RPA1, POLA1, POLA2	14	62	41.51	4.580e-5	1.205e-3
Pyrimidine biosynthesis	Reactome	2	CAD, UMPS	3	62	129.14	7.841e-5	1.861e-3