# GeDiPNet Cluster 82 -- Enriched Pathways -- generated 2026-10-07 10:03:01
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Reactome	2	FOXD3, SOX2	13	32	57.74	5.267e-4	8.285e-3
Crosslinking of collagen fibrils	Reactome	2	PXDN, COL4A1	18	32	41.70	1.025e-3	1.380e-2
Defective CYP1B1 causes Glaucoma	Reactome	1	CYP1B1	1	32	375.31	2.664e-3	2.827e-2
Retinoid metabolism disease events	Reactome	1	RBP4	1	32	375.31	2.664e-3	2.827e-2
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome	1	MC2R	2	32	187.66	5.322e-3	4.557e-2
Signaling pathways regulating pluripotency of stem cells	KEGG	3	PAX6, SOX2, BMP4	144	32	7.82	6.492e-3	5.197e-2
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	Reactome	1	SOX2	3	32	125.10	7.973e-3	5.956e-2
Ion homeostasis	Reactome	2	RYR1, ITPR1	54	32	13.90	9.028e-3	6.451e-2
Hedgehog 'off' state	Reactome	2	IFT140, PTCH1	56	32	13.40	9.684e-3	6.732e-2
TFAP2 (AP-2) family regulates transcription of other transcription factors	Reactome	1	PITX2	4	32	93.83	1.062e-2	7.123e-2
Long-term depression	KEGG	2	RYR1, ITPR1	60	32	12.51	1.106e-2	7.290e-2
Basal cell carcinoma	KEGG	2	BMP4, PTCH1	63	32	11.91	1.214e-2	7.697e-2
Cortisol synthesis and secretion	KEGG	2	ITPR1, MC2R	65	32	11.55	1.289e-2	7.945e-2
Melanin biosynthesis	Reactome	1	TYR	5	32	75.06	1.325e-2	8.074e-2
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	Reactome	1	PAX6	7	32	53.62	1.851e-2	9.846e-2