# GeDiPNet Cluster 77 -- Enriched Pathways -- generated 2026-10-07 12:20:46
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Telomere Extension By Telomerase	Reactome	10	TERT, DKC1, GAR1, NHP2, NOP10, POT1, RTEL1, TINF2, WRAP53, ACD	16	56	134.04	1.629e-20	1.353e-17
rRNA modification in the nucleus and cytosol	Reactome	4	DKC1, GAR1, NHP2, NOP10	12	56	71.49	2.041e-7	1.217e-5
Allograft rejection	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	39	56	27.50	9.371e-7	4.604e-5
Leishmaniasis	KEGG	6	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF, JAK2	78	56	16.50	1.549e-6	7.100e-5
Type I diabetes mellitus	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	44	56	24.37	1.736e-6	7.812e-5
Graft-versus-host disease	KEGG	5	IFNG, PRF1, HLA-DQA1, HLA-DQB1, TNF	45	56	23.83	1.947e-6	8.589e-5
Malaria	KEGG	5	CSF3, IFNG, TGFB1, TNF, ACKR1	50	56	21.45	3.317e-6	1.349e-4
Telomere C-strand synthesis initiation	Reactome	3	CTC1, POLA1, POLA2	7	56	91.91	3.317e-6	1.349e-4
Rheumatoid arthritis	KEGG	6	CSF2, IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF	95	56	13.55	4.931e-6	1.877e-4
Hematopoietic cell lineage	KEGG	6	CSF2, CSF3, HLA-DQA1, HLA-DQB1, THPO, TNF	100	56	12.87	6.643e-6	2.380e-4
Toxoplasmosis	KEGG	6	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF, JAK2	112	56	11.49	1.277e-5	4.115e-4
Inflammatory bowel disease	KEGG	5	IFNG, HLA-DQA1, HLA-DQB1, TGFB1, TNF	66	56	16.25	1.322e-5	4.233e-4
DNA Damage/Telomere Stress Induced Senescence	Reactome	5	NBN, POT1, TINF2, TP53, ACD	66	56	16.25	1.322e-5	4.233e-4
Removal of the Flap Intermediate	Reactome	3	RPA1, POLA1, POLA2	14	56	45.96	3.371e-5	9.221e-4
Pyrimidine biosynthesis	Reactome	2	CAD, UMPS	3	56	142.98	6.387e-5	1.557e-3