# GeDiPNet Cluster 74 -- Enriched Pathways -- generated 2026-10-07 03:07:09
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Renin-angiotensin system	KEGG	3	ACE, AGT, AGTR1	23	29	54.02	2.170e-5	6.392e-4
Hypertrophic cardiomyopathy	KEGG	4	ACE, AGT, TGFB2, RYR2	99	29	16.73	8.807e-5	2.024e-3
Diabetic cardiomyopathy	KEGG	5	ACE, AGT, AGTR1, TGFB2, RYR2	205	29	10.10	1.174e-4	2.549e-3
Renin secretion	KEGG	3	ACE, AGT, AGTR1	69	29	18.01	5.959e-4	9.144e-3
Metabolism of Angiotensinogen to Angiotensins	Reactome	2	ACE, AGT	17	29	48.72	7.487e-4	1.092e-2
VxPx cargo-targeting to cilium	Reactome	2	PKD1, PKD2	21	29	39.44	1.149e-3	1.507e-2
AGE-RAGE signaling pathway in diabetic complications	KEGG	3	AGT, AGTR1, TGFB2	101	29	12.30	1.800e-3	2.115e-2
Dilated cardiomyopathy	KEGG	3	AGT, TGFB2, RYR2	105	29	11.83	2.011e-3	2.289e-2
Peptide ligand-binding receptors	Reactome	3	AGT, AGTR1, KISS1R	106	29	11.72	2.066e-3	2.339e-2
Defective ALG8 causes ALG8-CDG (CDG-1h)	Reactome	1	ALG8	1	29	414.14	2.415e-3	2.621e-2
Vascular smooth muscle contraction	KEGG	3	AGT, AGTR1, BRAF	134	29	9.27	4.014e-3	3.776e-2
Synthesis of dolichyl-phosphate-glucose	Reactome	1	ALG5	2	29	207.07	4.824e-3	4.284e-2
Adrenergic signaling in cardiomyocytes	KEGG	3	AGT, AGTR1, RYR2	154	29	8.07	5.917e-3	4.894e-2
Cushing syndrome	KEGG	3	AGT, AGTR1, BRAF	155	29	8.02	6.024e-3	4.947e-2
Cysteine formation from homocysteine	Reactome	1	CBS	3	29	138.05	7.227e-3	5.583e-2