# GeDiPNet Cluster 73 -- Enriched Pathways -- generated 2026-10-07 03:56:25
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	47	AGER, AGT, CCL2, COL4A2, ICAM1, IL6, NOS3, SERPINE1, STAT3, TNF, VCAM1, VEGFA	101	1218	4.59	5.874e-21	5.406e-18
Lipid and atherosclerosis	KEGG	69	ABCA1, AGER, APOA1, APOA4, APOB, CCL2, CCL3, CYBA, FASLG, HSPA1A, HSPA1B, ICAM1	216	1218	3.15	6.219e-19	4.293e-16
Interleukin-4 and Interleukin-13 signaling	Reactome	45	ALOX15, ALOX5, CCL2, FASLG, ICAM1, IL6, MMP1, NOS2, PTGS2, SOCS3, STAT3, TNF	108	1218	4.11	8.696e-18	4.731e-15
Pathways in cancer	KEGG	115	AGT, COL4A2, EDNRA, ESR1, FASLG, GSTM1, IFNG, IGF2, IL6, MMP1, NOS2, NQO1	533	1218	2.13	1.178e-15	4.485e-13
Complement and coagulation cascades	KEGG	37	CLU, PLAT, SERPINE1, F2, F5, FGA, PLAU, F7, FGB, PROCR, PLG, CFH	88	1218	4.15	5.159e-15	1.732e-12
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	45	APOA1, APOB, APOE, IGF2, IL6, MMP1, ALB, F2, F5, FGA, AHSG, APOA5	125	1218	3.55	6.151e-15	2.040e-12
Platelet degranulation 	Reactome	44	APOA1, CLU, IGF2, SERPINE1, SOD1, VEGFA, ALB, F5, FGA, ITGA2B, ITGB3, TGFB1	123	1218	3.53	1.609e-14	4.789e-12
Cholesterol metabolism	KEGG	27	ABCA1, ABCG5, APOA1, APOA4, APOB, APOC1, APOE, CETP, CYP27A1, LDLR, LPA, NPC1	51	1218	5.22	2.307e-14	6.618e-12
Post-translational protein phosphorylation	Reactome	38	APOA1, APOB, APOE, IL6, ALB, F5, FGA, AHSG, APOA5, MIA3, APOL1, CST3	108	1218	3.47	1.818e-12	3.797e-10
HIF-1 signaling pathway	KEGG	38	IFNG, IL6, NOS2, NOS3, SERPINE1, STAT3, TLR4, VEGFA, EDN1, PIK3CA, EPO, HMOX1	110	1218	3.41	3.485e-12	6.825e-10
Fluid shear stress and atherosclerosis	KEGG	42	CCL2, CYBA, GSTM1, ICAM1, IFNG, NOS3, NQO1, PLAT, TNF, VCAM1, VEGFA, EDN1	141	1218	2.94	6.259e-11	9.372e-9
Malaria	KEGG	23	CCL2, ICAM1, IFNG, IL6, TLR4, TNF, VCAM1, IL1B, TGFB1, SELE, CD40LG, IL10	50	1218	4.54	8.257e-11	1.209e-8
Chagas disease	KEGG	34	CCL2, CCL3, FASLG, IFNG, IL6, NOS2, SERPINE1, TLR4, TNF, ACE, IL1B, PIK3CA	103	1218	3.25	1.971e-10	2.661e-8
African trypanosomiasis	KEGG	19	APOA1, FASLG, ICAM1, IFNG, IL6, TNF, VCAM1, IL1B, SELE, IL10, NPPA, APOL1	37	1218	5.06	3.383e-10	4.325e-8
Hormone signaling	KEGG	52	ADIPOQ, AGT, ESR1, IGF2, NPPB, STAT3, ITGAV, ITGB3, PIK3CA, AGTR1, ADRB3, EPO	219	1218	2.34	3.190e-9	3.160e-7