# GeDiPNet Cluster 70 -- Enriched Pathways -- generated 2026-10-07 13:55:31
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	6	ICAM1, TNF, AGT, NOS3, VEGFA, JAK2	101	45	15.85	1.902e-6	8.424e-5
Stimuli-sensing channels	Reactome	5	SCNN1B, SCNN1A, SCNN1G, WNK1, WNK4	79	45	16.89	1.077e-5	3.572e-4
Aldosterone-regulated sodium reabsorption	KEGG	4	SCNN1B, SCNN1A, SCNN1G, NR3C2	38	45	28.09	1.157e-5	3.783e-4
Hormone signaling	KEGG	6	AGT, AVP, JAK2, GNAS, PTH1R, GHSR	219	45	7.31	1.544e-4	3.183e-3
Interleukin-4 and Interleukin-13 signaling	Reactome	4	ICAM1, TNF, VEGFA, JAK2	108	45	9.88	6.938e-4	1.029e-2
Parathyroid hormone synthesis, secretion and action	KEGG	4	GNAS, WNK1, WNK4, PTH1R	115	45	9.28	8.782e-4	1.229e-2
Metabolism of Angiotensinogen to Angiotensins	Reactome	2	REN, AGT	17	45	31.40	1.801e-3	2.116e-2
Cortisol synthesis and secretion	KEGG	3	AGT, CYP17A1, GNAS	65	45	12.32	1.826e-3	2.135e-2
Fluid shear stress and atherosclerosis	KEGG	4	ICAM1, TNF, NOS3, VEGFA	141	45	7.57	1.867e-3	2.168e-2
Renin secretion	KEGG	3	REN, AGT, GNAS	69	45	11.60	2.167e-3	2.418e-2
Renin-angiotensin system	KEGG	2	REN, AGT	23	45	23.21	3.304e-3	3.300e-2
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	Reactome	1	CYP17A1	1	45	266.89	3.747e-3	3.595e-2
Taste transduction	KEGG	3	SCNN1B, SCNN1A, SCNN1G	86	45	9.31	4.050e-3	3.800e-2
Rheumatoid arthritis	KEGG	3	ICAM1, TNF, VEGFA	95	45	8.43	5.350e-3	4.574e-2
NF-kappa B signaling pathway	KEGG	3	ICAM1, TNF, LTBR	105	45	7.63	7.060e-3	5.493e-2