# GeDiPNet Cluster 67 -- Enriched Pathways -- generated 2026-10-08 20:59:21
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
AGE-RAGE signaling pathway in diabetic complications	KEGG	27	BCL2, CCND1, CYBB, FN1, IL6, PLCG1, RAC1, TGFB1, AGT, CCL2, COL4A1, NOS3	101	623	5.15	8.047e-13	1.673e-10
HIF-1 signaling pathway	KEGG	22	BCL2, CYBB, HK1, IL6, INS, INSR, PLCG1, TFRC, TLR4, CDKN1A, NOS3, RELA	110	623	3.86	3.805e-8	2.774e-6
PI3K-Akt signaling pathway	KEGG	43	BDNF, BCL2, CCND1, CCND2, CSF1R, FGFR3, FN1, IL6, INS, INSR, IRS1, ITGA2	361	623	2.30	2.739e-7	1.580e-5
Malaria	KEGG	13	IL6, TGFB1, THBS2, TLR4, CCL2, HBB, HGF, IFNG, GYPA, ICAM1, IL10, THBS1	50	623	5.01	1.042e-6	5.044e-5
Type I diabetes mellitus	KEGG	12	HLA-C, HLA-DQA1, HLA-DQA2, HLA-DQB1, INS, HLA-DRB1, IFNG, GAD2, HLA-B, LTA, PTPRN2, TNF	44	623	5.26	1.559e-6	7.123e-5
Interleukin-4 and Interleukin-13 signaling	Reactome	19	POMC, BCL2, CCND1, FN1, IL6, PTGS2, TGFB1, FGF2, CCL2, CDKN1A, VEGFA, JAK1	108	623	3.39	2.508e-6	1.081e-4
Type II diabetes mellitus	KEGG	12	ABCC8, ADIPOQ, GCK, HK1, INS, INSR, IRS1, KCNJ11, PRKCE, PIK3R1, TNF, HKDC1	47	623	4.92	3.347e-6	1.382e-4
Maturity onset diabetes of the young	KEGG	9	GCK, HHEX, HNF1A, HNF1B, HNF4A, INS, PAX4, PAX6, RFX6	26	623	6.67	3.619e-6	1.477e-4
Human T-cell leukemia virus 1 infection	KEGG	29	ADCY5, CALR, CCND1, CCND2, CDKN2C, CRTC1, ETS1, HLA-C, HLA-DQA1, HLA-DQA2, HLA-DQB1, IL6	224	623	2.50	4.846e-6	1.886e-4
Leishmaniasis	KEGG	15	CYBB, HLA-DQA1, HLA-DQA2, HLA-DQB1, NCF1, PTGS2, TGFB1, TLR4, RELA, HLA-DRB1, JAK1, IFNG	78	623	3.71	9.299e-6	3.226e-4
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	19	HRC, APOB, APOE, CP, FN1, IL6, MEN1, PCSK9, WFS1, ALB, GAS6, KLK1	125	623	2.93	2.246e-5	6.712e-4
Synthesis, secretion, and deacylation of Ghrelin	Reactome	7	PCSK1, CRHR2, INS, LEP, GHRL, GH1, IGF1	19	623	7.10	2.848e-5	8.146e-4
Fluid shear stress and atherosclerosis	KEGG	20	MAP2K5, BCL2, GSTM1, GSTT1, MAP3K5, NCF1, RAC1, CCL2, KDR, NFE2L2, NOS3, RELA	141	623	2.73	3.856e-5	1.045e-3
Proteoglycans in cancer	KEGG	25	ANK1, CCND1, FN1, ITGA2, PLCG1, RAC1, TGFB1, TLR4, FGF2, CDKN1A, KDR, VEGFA	204	623	2.36	5.498e-5	1.397e-3
EGFR tyrosine kinase inhibitor resistance	KEGG	14	BCL2, FGFR3, IL6, PDGFC, PLCG1, FGF2, AXL, GAS6, KDR, VEGFA, JAK1, HGF	80	623	3.37	5.544e-5	1.407e-3