# GeDiPNet Cluster 630 -- Pairs Within Cluster -- generated 2026-10-20 00:02:41
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:19.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome	Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities	0.33333	1	1.291e-4	3.269e-4
Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome	Progressive childhood encephalopathy and golgi dysfunction	0.33333	1	1.291e-4	3.269e-4
Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities	Lipoyltransferase deficiency	0.25000	1	1.937e-4	4.414e-4
Leigh syndrome with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase	Lipoyltransferase deficiency	0.25000	1	1.937e-4	4.414e-4
Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome	Lipoyltransferase deficiency	0.20000	1	3.874e-4	7.329e-4