# GeDiPNet Cluster 59 -- Pairs Within Cluster -- generated 2026-10-07 18:27:10
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 17:17:46.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Hypomyelinating leukodystrophy	Leukodystrophy	0.16327	8	1.142e-16	1.834e-15
Leukodystrophy	Tremor-ataxia-central hypomyelination syndrome	0.07407	2	2.742e-6	1.493e-5
Hypomyelinating leukodystrophy	Tremor-ataxia-central hypomyelination syndrome	0.06452	2	3.670e-6	1.959e-5
POLR3A-related disorder	Wiedemann-rautenstrauch syndrome	0.50000	1	6.494e-5	2.317e-4
Tremor-ataxia-central hypomyelination syndrome	Wiedemann-rautenstrauch syndrome	0.33333	1	1.299e-4	3.908e-4
POLR3B-related disorder	Tremor-ataxia-central hypomyelination syndrome	0.33333	1	1.299e-4	3.908e-4
POLR3A-related disorder	Tremor-ataxia-central hypomyelination syndrome	0.33333	1	1.299e-4	3.908e-4
Developmental delay with dysmorphic facies and brain anomalies	Leukodystrophy	0.03704	1	1.689e-3	2.529e-3
Leukodystrophy	Wiedemann-rautenstrauch syndrome	0.03704	1	1.689e-3	2.529e-3
hypomyelinating leukodystrophy 9	Leukodystrophy	0.03704	1	1.689e-3	2.529e-3
Leukodystrophy	POLR3B-related disorder	0.03704	1	1.689e-3	2.529e-3
Leukodystrophy	leukodystrophy, hypomyelinating, 18	0.03704	1	1.689e-3	2.529e-3
Leukodystrophy	POLR3A-related disorder	0.03704	1	1.689e-3	2.529e-3
Hypomyelinating leukodystrophy	Wiedemann-rautenstrauch syndrome	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	VPS11-related neurological disorder	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	POLR3A-related disorder	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	leukodystrophy, hypomyelinating, 22	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	leukodystrophy, hypomyelinating, 21	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	leukodystrophy, hypomyelinating, 18	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	leukodystrophy, hypomyelinating, 17	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	leukodystrophy, hypomyelinating, 14	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	hypomyelinating leukodystrophy 9	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	hypomyelinating leukodystrophy 5	0.03226	1	1.948e-3	2.826e-3
Hypomyelinating leukodystrophy	POLR3B-related disorder	0.03226	1	1.948e-3	2.826e-3