# GeDiPNet Cluster 59 -- Enriched Pathways -- generated 2026-10-08 02:19:28
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Defective B3GALTL causes Peters-plus syndrome (PpS)	Reactome	5	ADAMTS2, ADAMTSL2, ADAMTSL4, ADAMTS17, ADAMTS10	37	19	85.42	2.362e-9	2.329e-7
O-glycosylation of TSR domain-containing proteins	Reactome	5	ADAMTS2, ADAMTSL2, ADAMTSL4, ADAMTS17, ADAMTS10	38	19	83.17	2.717e-9	2.647e-7
Molecules associated with elastic fibres	Reactome	4	GDF5, FBN1, LTBP3, LTBP2	38	19	66.54	3.192e-7	1.811e-5
TGF-beta signaling pathway	KEGG	4	BMPR1B, GDF5, FBN1, BMPR2	108	19	23.41	2.160e-5	6.499e-4
Signaling by BMP	Reactome	2	BMPR1B, BMPR2	28	19	45.15	8.746e-4	1.254e-2
Hippo signaling pathway	KEGG	3	BMPR1B, GDF5, BMPR2	157	19	12.08	1.821e-3	2.177e-2
Hormone signaling	KEGG	3	NPR2, BMPR1B, PRKG2	219	19	8.66	4.671e-3	4.247e-2
STING mediated induction of host immune responses	Reactome	1	DDX41	5	19	126.42	7.886e-3	6.037e-2
Cytokine-cytokine receptor interaction	KEGG	3	BMPR1B, GDF5, BMPR2	298	19	6.36	1.091e-2	7.412e-2
Prevention of phagosomal-lysosomal fusion	Reactome	1	VPS33B	9	19	70.23	1.415e-2	8.635e-2
cGMP effects	Reactome	1	PRKG2	11	19	57.46	1.727e-2	9.767e-2
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Reactome	1	PRKG2	11	19	57.46	1.727e-2	9.767e-2
Physiological factors	Reactome	1	NPR2	12	19	52.68	1.883e-2	1.026e-1
IRF3-mediated induction of type I IFN	Reactome	1	DDX41	13	19	48.62	2.038e-2	1.069e-1
Fluid shear stress and atherosclerosis	KEGG	2	BMPR1B, BMPR2	141	19	8.97	2.054e-2	1.075e-1