# GeDiPNet Cluster 58 -- Enriched Pathways -- generated 2026-10-07 06:28:22
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Hormone ligand-binding receptors	Reactome	5	FSHB, GNRH1, GNRHR, LHB, LHCGR	12	164	30.51	3.275e-7	1.852e-5
Hormone signaling	KEGG	13	FSHB, GNRH1, GNRHR, LEP, LEPR, LHB, PRL, GH1, GHRHR, GNAI2, GHR, CSHL1	219	164	4.35	9.347e-6	3.172e-4
FGFR1c ligand binding and activation	Reactome	4	ANOS1, FGF17, FGF8, FGFR1	12	164	24.41	1.523e-5	4.770e-4
Neuroactive ligand-receptor interaction	KEGG	16	FSHB, GNRH1, GNRHR, KISS1R, LEP, LEPR, LHB, PRL, TAC3, TACR3, GH1, GHRHR	370	164	3.17	4.603e-5	1.194e-3
FGFR3b ligand binding and activation	Reactome	3	FGF17, FGF8, FGFR3	7	164	31.39	8.405e-5	1.948e-3
Downstream signaling of activated FGFR1	Reactome	4	FGF17, FGF8, FGFR1, FLRT3	18	164	16.27	8.833e-5	2.028e-3
Axon guidance	KEGG	10	PLXNA3, SEMA3A, SEMA3E, SEMA3F, GNAI2, ROBO1, DCC, PTCH1, RAF1, SEMA5A	183	164	4.00	2.042e-4	3.966e-3
Steroid hormone biosynthesis	KEGG	6	AKR1C4, CYP17A1, CYP19A1, SRD5A2, UGT2B10, UGT2B15	63	164	6.97	2.113e-4	4.078e-3
Androgen biosynthesis	Reactome	3	CYP17A1, LHB, SRD5A2	11	164	19.97	3.806e-4	6.453e-3
Signaling by activated point mutants of FGFR1	Reactome	3	FGF17, FGF8, FGFR1	11	164	19.97	3.806e-4	6.453e-3
Negative regulation of FGFR1 signaling	Reactome	4	ANOS1, FGF17, FGF8, FGFR1	26	164	11.27	3.963e-4	6.661e-3
Glycoprotein hormones	Reactome	3	CGB3, FSHB, LHB	12	164	18.31	5.024e-4	7.988e-3
Prolactin receptor signaling	Reactome	3	PRL, GH1, GHR	12	164	18.31	5.024e-4	7.988e-3
Signaling by activated point mutants of FGFR3	Reactome	3	FGF17, FGF8, FGFR3	12	164	18.31	5.024e-4	7.988e-3
FGFR3 mutant receptor activation	Reactome	3	FGF17, FGF8, FGFR3	12	164	18.31	5.024e-4	7.988e-3