# GeDiPNet Cluster 563 -- Enriched Pathways -- generated 2026-10-20 00:03:15
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Melanoma	KEGG	8	TP53, CDKN2A, PDGFRA, KRAS, BRAF, FGFR1, PIK3CA, RB1	73	19	69.27	8.995e-14	2.135e-11
Chronic myeloid leukemia	KEGG	8	TP53, CDKN2A, KRAS, STAT5B, PTPN11, BRAF, PIK3CA, RB1	77	19	65.67	1.404e-13	3.162e-11
Prostate cancer	KEGG	8	TP53, PDGFRA, CTNNB1, KRAS, BRAF, FGFR1, PIK3CA, RB1	98	19	51.60	1.032e-12	1.959e-10
Pathways in cancer	KEGG	12	TP53, CDKN2A, PDGFRA, CTNNB1, KRAS, STAT5B, SUFU, BRAF, FGFR1, PIK3CA, MLH1, RB1	533	19	14.23	1.961e-12	3.485e-10
Non-small cell lung cancer	KEGG	7	TP53, CDKN2A, KRAS, STAT5B, BRAF, PIK3CA, RB1	73	19	60.61	1.085e-11	1.638e-9
Glioma	KEGG	7	TP53, CDKN2A, PDGFRA, KRAS, BRAF, PIK3CA, RB1	76	19	58.22	1.453e-11	2.114e-9
Endometrial cancer	KEGG	6	TP53, CTNNB1, KRAS, BRAF, PIK3CA, MLH1	59	19	64.28	2.796e-10	2.954e-8
Downstream signal transduction	Reactome	5	PDGFRA, KRAS, STAT5B, PTPN11, PIK3CA	29	19	108.98	6.484e-10	6.333e-8
Pancreatic cancer	KEGG	6	TP53, CDKN2A, KRAS, BRAF, PIK3CA, RB1	77	19	49.25	1.447e-9	1.299e-7
Breast cancer	KEGG	7	TP53, CTNNB1, KRAS, BRAF, FGFR1, PIK3CA, RB1	148	19	29.90	1.666e-9	1.470e-7
Gastric cancer	KEGG	7	TP53, CTNNB1, KRAS, BRAF, PIK3CA, MLH1, RB1	150	19	29.50	1.831e-9	1.601e-7
Colorectal cancer	KEGG	6	TP53, CTNNB1, KRAS, BRAF, PIK3CA, MLH1	87	19	43.59	3.052e-9	2.556e-7
Bladder cancer	KEGG	5	TP53, CDKN2A, KRAS, BRAF, RB1	41	19	77.09	4.044e-9	3.298e-7
Hepatocellular carcinoma	KEGG	7	TP53, CDKN2A, CTNNB1, KRAS, BRAF, PIK3CA, RB1	170	19	26.03	4.394e-9	3.547e-7
Endocrine resistance	KEGG	6	TP53, CDKN2A, KRAS, BRAF, PIK3CA, RB1	99	19	38.31	6.698e-9	5.175e-7