# GeDiPNet Cluster 55 -- Enriched Pathways -- generated 2026-10-08 07:09:51
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Relaxin signaling pathway	KEGG	8	COL1A1, TGFBR1, TGFBR2, MMP2, MMP9, COL3A1, GNG2, MMP1	130	82	9.01	2.764e-6	1.176e-4
AGE-RAGE signaling pathway in diabetic complications	KEGG	7	AGT, COL1A1, SMAD3, TGFBR1, TGFBR2, MMP2, COL3A1	101	82	10.15	5.473e-6	2.086e-4
SMAD2/3 Phosphorylation Motif Mutants in Cancer	Reactome	3	SMAD3, TGFBR1, TGFBR2	6	82	73.23	6.046e-6	2.253e-4
TGFBR1 KD Mutants in Cancer	Reactome	3	SMAD3, TGFBR1, TGFBR2	6	82	73.23	6.046e-6	2.253e-4
Collagen degradation	Reactome	5	COL1A1, MMP2, MMP9, COL3A1, MMP1	52	82	14.08	2.651e-5	7.686e-4
TGF-beta receptor signaling activates SMADs	Reactome	3	SMAD3, TGFBR1, TGFBR2	12	82	36.62	6.456e-5	1.589e-3
Activation of Matrix Metalloproteinases	Reactome	4	MMP2, MMP9, TIMP1, MMP1	33	82	17.75	7.104e-5	1.714e-3
Diabetic cardiomyopathy	KEGG	8	AGT, COL1A1, SMAD3, TGFBR1, TGFBR2, MMP2, MMP9, COL3A1	205	82	5.72	7.592e-5	1.811e-3
TGF-beta signaling pathway	KEGG	6	SMAD3, TGFBR1, TGFBR2, FBN1, SMAD6, SKI	108	82	8.14	9.252e-5	2.131e-3
Degradation of the extracellular matrix	Reactome	5	FBN1, MMP2, MMP9, ELN, MMP1	70	82	10.46	1.121e-4	2.487e-3
Molecules associated with elastic fibres	Reactome	4	FBN1, EFEMP2, EMILIN1, ELN	38	82	15.42	1.249e-4	2.708e-3
TGFBR2 Kinase Domain Mutants in Cancer	Reactome	2	TGFBR1, TGFBR2	3	82	97.64	1.375e-4	2.930e-3
Downregulation of TGF-beta receptor signaling	Reactome	3	SMAD3, TGFBR1, TGFBR2	16	82	27.46	1.611e-4	3.320e-3
Integrin cell surface interactions	Reactome	5	COL1A1, FBN1, COL3A1, COL16A1, TNC	81	82	9.04	2.239e-4	4.313e-3
Elastic fibre formation	Reactome	3	FBN1, LOX, ELN	18	82	24.41	2.325e-4	4.443e-3