# GeDiPNet Cluster 54 -- Enriched Pathways -- generated 2026-10-08 02:17:29
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
ECM proteoglycans	Reactome	11	ACAN, ITGB5, VCAN, COMP, COL2A1, COL9A1, COL9A2, COL9A3, HSPG2, MATN3, BGN	51	122	21.23	2.542e-12	4.805e-10
Non-integrin membrane-ECM interactions	Reactome	7	COL10A1, COL11A1, COL11A2, TTR, COL2A1, HSPG2, DDR2	24	122	28.71	2.815e-9	2.733e-7
Focal adhesion	KEGG	14	ITGB5, MYL7, THBS3, COMP, COL2A1, BCL2, COL9A1, COL9A2, COL9A3, FLNA, FLNB, FLT1	203	122	6.79	1.708e-8	1.361e-6
Assembly of collagen fibrils and other multimeric structures	Reactome	8	COL10A1, COL11A1, COL11A2, COL2A1, COL9A1, COL9A2, COL9A3, MMP13	51	122	15.44	3.977e-8	2.886e-6
Collagen chain trimerization	Reactome	7	COL10A1, COL11A1, COL11A2, COL2A1, COL9A1, COL9A2, COL9A3	44	122	15.66	2.634e-7	1.526e-5
Collagen biosynthesis and modifying enzymes	Reactome	8	ADAMTS14, COL10A1, COL11A1, COL11A2, COL2A1, COL9A1, COL9A2, COL9A3	67	122	11.75	3.557e-7	1.988e-5
Cytoskeleton in muscle cells	KEGG	13	COL11A1, COL11A2, FBN2, ITGB5, MYL7, THBS3, VCAN, COMP, COL9A1, COL9A2, COL9A3, HSPG2	232	122	5.52	6.363e-7	3.285e-5
Integrin cell surface interactions	Reactome	8	ITGB5, COMP, COL2A1, COL9A1, COL9A2, COL9A3, HSPG2, KDR	81	122	9.72	1.558e-6	7.122e-5
ECM-receptor interaction	KEGG	8	ITGB5, THBS3, COMP, COL2A1, COL9A1, COL9A2, COL9A3, HSPG2	89	122	8.85	3.198e-6	1.332e-4
Signaling by PDGF	Reactome	5	THBS3, COL2A1, COL9A1, COL9A2, COL9A3	33	122	14.92	1.883e-5	5.810e-4
Molecules associated with elastic fibres	Reactome	5	EFEMP1, FBN2, ITGB5, LTBP1, TGFB1	38	122	12.95	3.824e-5	1.040e-3
Defective B3GALT6 causes EDSP2 and SEMDJL1	Reactome	4	VCAN, HSPG2, B3GALT6, BGN	20	122	19.69	4.330e-5	1.156e-3
NCAM1 interactions	Reactome	4	COL2A1, COL9A1, COL9A2, COL9A3	21	122	18.75	5.307e-5	1.358e-3
Defective CHST3 causes SEDCJD	Reactome	3	VCAN, CHST3, BGN	8	122	36.92	5.518e-5	1.401e-3
VEGF binds to VEGFR leading to receptor dimerization	Reactome	3	FLT1, KDR, VEGFA	8	122	36.92	5.518e-5	1.401e-3