# GeDiPNet Cluster 52 -- Enriched Pathways -- generated 2026-10-08 12:57:34
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Reactome	2	FOXD3, SOX2	13	27	68.43	3.739e-4	6.480e-3
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Reactome	2	PAX6, CTNNB1	14	27	63.54	4.356e-4	7.319e-3
Interleukin-4 and Interleukin-13 signaling	Reactome	3	SOX2, MUC1, VIM	108	27	12.36	1.768e-3	2.129e-2
Cytochrome P450 - arranged by substrate type	Reactome	1	POR	1	27	444.81	2.248e-3	2.539e-2
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	Reactome	1	SLC2A1	1	27	444.81	2.248e-3	2.539e-2
Deactivation of the beta-catenin transactivating complex	Reactome	2	SOX2, CTNNB1	42	27	21.18	3.965e-3	3.809e-2
Signaling pathways regulating pluripotency of stem cells	KEGG	3	PAX6, SOX2, CTNNB1	144	27	9.27	3.999e-3	3.824e-2
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Reactome	1	IGF2BP3	3	27	148.27	6.730e-3	5.441e-2
Lactose synthesis	Reactome	1	SLC2A1	3	27	148.27	6.730e-3	5.441e-2
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	Reactome	1	SOX2	3	27	148.27	6.730e-3	5.441e-2
TFAP2 (AP-2) family regulates transcription of other transcription factors	Reactome	1	PITX2	4	27	111.20	8.963e-3	6.534e-2
Activated NTRK2 signals through PLCG1	Reactome	1	BDNF	4	27	111.20	8.963e-3	6.534e-2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	Reactome	1	CTNNB1	5	27	88.96	1.119e-2	7.510e-2
NTRK2 activates RAC1	Reactome	1	BDNF	5	27	88.96	1.119e-2	7.510e-2
Activated NTRK2 signals through FRS2 and FRS3	Reactome	1	BDNF	6	27	74.14	1.342e-2	8.370e-2