# GeDiPNet Cluster 51 -- Enriched Pathways -- generated 2026-10-09 06:01:06
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:30:08.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Cholesterol metabolism	KEGG	23	APOC2, LDLR, LPL, PLTP, APOB, LDLRAP1, PCSK9, ABCG8, ANGPTL4, APOC1, APOE, CYP7A1	51	216	25.08	2.815e-27	5.820e-24
Chylomicron remodeling	Reactome	9	APOC2, LPL, APOA5, APOB, APOE, APOA1, APOA2, APOC3, GPIHBP1	9	216	55.60	1.668e-16	6.634e-14
Chylomicron assembly	Reactome	7	APOC2, APOB, APOE, APOA1, APOA2, APOC3, MTTP	9	216	43.25	1.930e-11	3.029e-9
Chylomicron clearance	Reactome	5	LDLR, APOB, LDLRAP1, APOE, LIPC	5	216	55.60	1.797e-9	1.782e-7
Fat digestion and absorption	KEGG	10	APOB, ABCG8, PLA2G12B, ABCA1, ABCG5, APOA1, APOA4, MTTP, NPC1L1, SCARB1	43	216	12.93	3.284e-9	3.096e-7
HDL remodeling	Reactome	6	APOC2, PLTP, APOE, CETP, APOA1, APOC3	10	216	33.36	6.246e-9	5.492e-7
Lipid and atherosclerosis	KEGG	18	LDLR, PPARG, APOB, ABCA1, ICAM1, NCF1, NOX1, SELE, VCAM1, APOA1, APOA4, CCL2	216	216	4.63	6.539e-8	4.376e-6
Bile secretion	KEGG	12	LDLR, ABCG8, CYP7A1, HMGCR, BAAT, EPHX1, SLC10A1, ABCG5, ABCB1, SCARB1, UGT2B15, UGT2B17	90	216	7.41	6.736e-8	4.498e-6
PPAR signaling pathway	KEGG	11	LPL, PLTP, PPARA, PPARG, APOA5, ANGPTL4, CYP7A1, FADS2, APOA1, APOA2, APOC3	76	216	8.05	1.015e-7	6.414e-6
PPARA activates gene expression	Reactome	13	PEX11A, PPARA, PPARG, APOA5, ANGPTL4, CYP7A1, HMGCR, FADS1, ABCA1, SREBF2, APOA1, APOA2	115	216	6.29	1.395e-7	8.448e-6
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Reactome	8	APOC2, PLTP, ABCG8, APOC1, APOE, CETP, ABCA1, ABCG5	37	216	12.02	2.370e-7	1.333e-5
Retinoid metabolism and transport	Reactome	8	APOC2, LPL, APOB, APOE, APOA1, APOA2, APOC3, GPIHBP1	41	216	10.85	5.515e-7	2.786e-5
Assembly of active LPL and LIPC lipase complexes	Reactome	5	LPL, ANGPTL4, LIPC, GPIHBP1, LMF1	11	216	25.27	7.601e-7	3.679e-5
AGE-RAGE signaling pathway in diabetic complications	KEGG	11	VEGFA, COL3A1, EDN1, ICAM1, NOX1, SELE, VCAM1, CCL2, JAK2, NOS3, AKT1	101	216	6.06	1.901e-6	8.084e-5
Type I diabetes mellitus	KEGG	7	HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1, FASLG, INS	44	216	8.85	1.202e-5	3.798e-4