# GeDiPNet Cluster 50 -- Pairs Within Cluster -- generated 2026-10-07 20:05:13
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected across all tested pairs. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 17:17:46.
Disease A	Disease B	Similarity Score	Shared Genes	P-value	FDR Q-value
Marfan syndrome	Thoracic aortic aneurysm and aortic dissection	0.49123	28	4.645e-67	3.239e-65
Aneurysm	Aortic aneurysm	0.36364	24	5.637e-57	3.285e-55
Aortic aneurysm	Thoracic aortic aneurysm and aortic dissection	0.28395	23	1.480e-46	7.218e-45
Congenital contractural arachnodactyly	Thoracic aortic aneurysm and aortic dissection	0.33962	18	1.880e-41	8.193e-40
Congenital contractural arachnodactyly	Marfan syndrome	0.32727	18	5.651e-41	2.437e-39
Aortic aneurysm	Marfan syndrome	0.23256	20	3.654e-38	1.462e-36
Loeys-dietz syndrome	Marfan syndrome	0.30435	14	1.951e-35	7.148e-34
Ehlers-danlos syndrome	Thoracic aortic aneurysm and aortic dissection	0.24638	17	2.333e-34	8.257e-33
familial thoracic aortic aneurysm and aortic dissection	Thoracic aortic aneurysm and aortic dissection	0.28571	12	2.139e-32	7.113e-31
Loeys-dietz syndrome	Thoracic aortic aneurysm and aortic dissection	0.28889	13	2.246e-32	7.458e-31
Ehlers-danlos syndrome	Marfan syndrome	0.20548	15	6.730e-29	1.983e-27
familial thoracic aortic aneurysm and aortic dissection	Marfan syndrome	0.24444	11	2.392e-28	6.911e-27
Congenital aneurysm of ascending aorta	Thoracic aortic aneurysm and aortic dissection	0.22727	10	3.581e-25	8.843e-24
Congenital contractural arachnodactyly	Loeys-dietz syndrome	0.27778	10	7.739e-25	1.882e-23
Aortic aneurysm	Congenital contractural arachnodactyly	0.16456	13	1.230e-24	2.942e-23
Congenital contractural arachnodactyly	Ehlers-danlos syndrome	0.19355	12	2.869e-24	6.734e-23
Aortic aneurysm	Congenital aneurysm of ascending aorta	0.15385	10	3.426e-23	7.607e-22
Ehlers-danlos syndrome	Loeys-dietz syndrome	0.19608	10	9.536e-23	2.048e-21
Congenital aneurysm of ascending aorta	Loeys-dietz syndrome	0.26087	6	3.988e-16	6.165e-15
Congenital contractural arachnodactyly	familial thoracic aortic aneurysm and aortic dissection	0.16667	6	2.355e-14	3.218e-13
Congenital aneurysm of ascending aorta	familial thoracic aortic aneurysm and aortic dissection	0.25000	5	8.678e-14	1.134e-12
familial thoracic aortic aneurysm and aortic dissection	Loeys-dietz syndrome	0.20833	5	4.779e-13	5.972e-12
Ehlers-danlos syndrome	Keratoconus	0.05405	8	8.069e-10	7.390e-9
Marfan syndrome	Mitral valve prolapse	0.05814	5	1.879e-7	1.253e-6
Ehlers-danlos syndrome	Mitral valve prolapse	0.05747	5	2.115e-7	1.406e-6
Keratoconus	Thoracic aortic aneurysm and aortic dissection	0.04082	6	4.485e-7	2.822e-6
Keratoconus	Marfan syndrome	0.03333	5	1.376e-5	6.685e-5
Loeys-dietz syndrome	loeys-dietz syndrome 6	0.05882	1	1.039e-3	1.737e-3
Aneurysm	neonatal/infantile epilepsy syndrome	0.03571	1	1.753e-3	2.607e-3
Boudin-mortier syndrome	Congenital contractural arachnodactyly	0.03333	1	1.883e-3	2.760e-3
Congenital contractural arachnodactyly	loeys-dietz syndrome 6	0.03333	1	1.883e-3	2.760e-3
Boudin-mortier syndrome	Marfan syndrome	0.02273	1	2.793e-3	3.747e-3
Ehlers-danlos syndrome	ehlers-danlos syndrome, musculocontractural type 2	0.02222	1	2.858e-3	3.805e-3
Aneurysm	Vitreous body disease	0.03448	1	3.504e-3	4.517e-3
Aortic aneurysm	neonatal/infantile epilepsy syndrome	0.01587	1	4.026e-3	5.086e-3
Aortic aneurysm	Vitreous body disease	0.01563	1	8.037e-3	9.341e-3