# GeDiPNet Cluster 498 -- Enriched Pathways -- generated 2026-10-19 23:22:06
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Thyroid hormone synthesis	KEGG	3	SLC26A4, SLC5A5, DUOX2	75	5	96.08	2.318e-6	8.556e-5
Thyroxine biosynthesis	Reactome	2	SLC5A5, DUOX2	7	5	686.29	2.910e-6	1.038e-4
Defective SLC26A4 causes Pendred syndrome (PDS)	Reactome	1	SLC26A4	1	5	2402.00	4.163e-4	5.794e-3
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	Reactome	1	SLC5A5	1	5	2402.00	4.163e-4	5.794e-3
Multifunctional anion exchangers	Reactome	1	SLC26A4	9	5	266.89	3.742e-3	2.976e-2
Organic anion transporters	Reactome	1	SLC5A5	10	5	240.20	4.157e-3	3.210e-2