# GeDiPNet Cluster 49 -- Top Shared Genes -- generated 2026-10-08 11:15:24
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-08 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
MSX1	7	14	Cleft lip; Cleft lip and palate; Cleft palate; Complete unilateral cleft lip; Craniosynostosis; Orofacial cleft; Tooth agenesis
FGFR1	6	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Craniosynostosis; Orofacial cleft; Tooth agenesis
IRF6	6	14	Cleft lip; Cleft lip and palate; Cleft palate; Complete unilateral cleft lip; Orofacial cleft; Tooth agenesis
BMP4	5	14	Cleft lip; Cleft lip and palate; Complete unilateral cleft lip; Orofacial cleft; Tooth agenesis
CDH1	5	14	Cleft lip; Cleft lip and palate; Cleft palate; Complete unilateral cleft lip; Orofacial cleft
FGF10	5	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Craniosynostosis; Orofacial cleft
NECTIN1	5	14	Cleft lip; Cleft lip and palate; Cleft palate; Complete unilateral cleft lip; Orofacial cleft
TP63	5	14	Cleft lip; Cleft lip and palate; Cleft palate; Complete unilateral cleft lip; Orofacial cleft
AXIN2	4	14	Craniosynostosis; oligodontia-cancer predisposition syndrome; Orofacial cleft; Tooth agenesis
FGFR2	4	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Craniosynostosis
FGFR3	4	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Craniosynostosis
NOG	4	14	Cleft lip; Complete unilateral cleft lip; Craniosynostosis; Orofacial cleft
PTCH1	4	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Craniosynostosis
SUMO1	4	14	Cleft lip; Cleft palate; Complete unilateral cleft lip; Orofacial cleft
ABCA4	3	14	Cleft lip; Complete unilateral cleft lip; Orofacial cleft
ARHGAP29	3	14	Cleft lip and palate; Cleft palate; Orofacial cleft
BHMT2	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
DLG1	3	14	Cleft lip and palate; Cleft palate; Orofacial cleft
FGF2	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
FGF3	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
FGF7	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
FGF8	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
FGF9	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
GDF6	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
KIF7	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
MAFB	3	14	Cleft lip; Complete unilateral cleft lip; Orofacial cleft
MTHFD1	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
MTHFR	3	14	Cleft lip; Complete unilateral cleft lip; Orofacial cleft
MTHFS	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
MTR	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
MYC	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
NOS3	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
SDC2	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
SLC19A1	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
SPRY2	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
TYMS	3	14	Cleft lip; Cleft palate; Complete unilateral cleft lip
AMOTL1	2	14	Cleft lip and palate; Orofacial cleft
BMP2	2	14	Craniosynostosis; Tooth agenesis
COL2A1	2	14	Cleft palate; Orofacial cleft
DLX4	2	14	Cleft lip and palate; Orofacial cleft
FGF1	2	14	Cleft lip; Complete unilateral cleft lip
FLNA	2	14	Craniosynostosis; Orofacial cleft
GDF11	2	14	Orofacial cleft; Vertebral hypersegmentation with orofacial anomalies
GLI3	2	14	Craniosynostosis; Tooth agenesis
GREM2	2	14	Tooth agenesis; tooth agenesis, selective, 9
IL11RA	2	14	Craniosynostosis; craniosynostosis and dental anomalies
LRP6	2	14	Orofacial cleft; Tooth agenesis
MEIS2	2	14	Cleft palate; Orofacial cleft
MMP9	2	14	Orofacial cleft; Tooth agenesis
MSX2	2	14	Craniosynostosis; Tooth agenesis
PAX9	2	14	Tooth agenesis; tooth agenesis, selective, 3
PDGFRA	2	14	Cleft lip and palate; Cleft palate
POMT1	2	14	Cleft lip; Complete unilateral cleft lip
RIC1	2	14	Catifa syndrome; Cleft lip and palate
RUNX2	2	14	Craniosynostosis; Orofacial cleft
RYK	2	14	Cleft palate; Orofacial cleft
TBX22	2	14	Cleft palate; Orofacial cleft
TCN2	2	14	Cleft lip; Complete unilateral cleft lip
ZNF462	2	14	Craniosynostosis; Weiss-kruszka syndrome