# GeDiPNet Cluster 49 -- Enriched Pathways -- generated 2026-10-08 00:48:35
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-08 03:30:07.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Gastric cancer	KEGG	23	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, MYC, EGF, FZD4, TGFB1, TGFB2	150	290	6.35	1.254e-12	2.498e-10
Pathways in cancer	KEGG	41	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, MYC, PTCH1, CHUK	533	290	3.19	3.665e-11	5.536e-9
Hippo signaling pathway	KEGG	21	MYC, DLG1, FZD4, GDF6, TGFB1, TGFB2, TGFB3, BMP4, CDH1, FGF1, BMP2, AXIN2	157	290	5.54	1.744e-10	2.272e-8
TGF-beta signaling pathway	KEGG	17	MYC, GDF6, TGFB1, TGFB2, TGFB3, BMP4, NOG, BMP2, SMAD6, FBN1, TGFBR1, GREM2	108	290	6.52	7.704e-10	8.482e-8
Activated point mutants of FGFR2	Reactome	8	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, FGF1	17	290	19.49	2.113e-9	2.107e-7
Constitutive Signaling by Aberrant PI3K in Cancer	Reactome	14	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, EGF, PDGFRA, FGF1	75	290	7.73	2.505e-9	2.458e-7
Breast cancer	KEGG	19	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, MYC, EGF, FZD4, FGF1, AXIN2	148	290	5.32	2.673e-9	2.609e-7
MAPK signaling pathway	KEGG	27	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, MYC, CHUK, EGF	299	290	3.74	3.501e-9	3.337e-7
Phospholipase C-mediated cascade; FGFR2	Reactome	8	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, FGF1	18	290	18.41	3.724e-9	3.529e-7
RAF/MAP kinase cascade	Reactome	17	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, DLG1, EGF, PDGFRA	124	290	5.68	6.819e-9	6.034e-7
Negative regulation of FGFR2 signaling	Reactome	9	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, UBB, FGF1	27	290	13.80	7.891e-9	6.867e-7
PI3K Cascade	Reactome	10	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGF1	39	290	10.62	1.976e-8	1.548e-6
FGFR2b ligand binding and activation	Reactome	6	FGF10, FGF2, FGF3, FGF7, FGFR2, FGF1	10	290	24.85	3.645e-8	2.677e-6
PI-3K cascade:FGFR2	Reactome	8	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, FGF1	23	290	14.40	3.756e-8	2.744e-6
SHC-mediated cascade:FGFR2	Reactome	8	FGF10, FGF2, FGF3, FGF7, FGF8, FGF9, FGFR2, FGF1	23	290	14.40	3.756e-8	2.744e-6