# GeDiPNet Cluster 481 -- Enriched Pathways -- generated 2026-10-20 00:02:25
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Deactivation of the beta-catenin transactivating complex	Reactome	3	TCF7L1, SOX2, SOX3	42	22	38.99	5.848e-5	1.235e-3
Basal cell carcinoma	KEGG	3	GLI2, TCF7L1, SHH	63	22	26.00	1.973e-4	3.246e-3
Signaling by FGFR1 amplification mutants	Reactome	1	FGFR1	1	22	545.91	1.832e-3	1.781e-2
Signaling pathways regulating pluripotency of stem cells	KEGG	3	HESX1, FGFR1, SOX2	144	22	11.37	2.200e-3	2.042e-2
Pathways in cancer	KEGG	5	GLI2, TCF7L1, ARNT2, FGFR1, SHH	533	22	5.12	2.373e-3	2.158e-2
Hippo signaling pathway	KEGG	3	GLI2, TCF7L1, SOX2	157	22	10.43	2.812e-3	2.434e-2
Hedgehog signaling pathway	KEGG	2	GLI2, SHH	56	22	19.50	4.646e-3	3.479e-2
Signaling by plasma membrane FGFR1 fusions	Reactome	1	FGFR1	3	22	181.97	5.486e-3	3.872e-2
FGFR1c and Klotho ligand binding and activation	Reactome	1	FGFR1	3	22	181.97	5.486e-3	3.872e-2
GLI proteins bind promoters of Hh responsive genes to promote transcription	Reactome	1	GLI2	3	22	181.97	5.486e-3	3.872e-2
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	Reactome	1	SOX2	3	22	181.97	5.486e-3	3.872e-2
Regulation of commissural axon pathfinding by SLIT and ROBO	Reactome	1	ROBO1	3	22	181.97	5.486e-3	3.872e-2
Role of ABL in ROBO-SLIT signaling	Reactome	1	ROBO1	4	22	136.48	7.308e-3	4.669e-2
HHAT G278V abrogates palmitoylation of Hh-Np	Reactome	1	SHH	4	22	136.48	7.308e-3	4.669e-2
SLIT2:ROBO1 increases RHOA activity	Reactome	1	ROBO1	4	22	136.48	7.308e-3	4.669e-2